Secretory microRNA-29 expression in gingival crevicular fluid during orthodontic tooth movement

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Secretory microRNA-29 expression in gingival crevicular fluid during orthodontic tooth movement

Secretory microRNAs (miRNAs) have been used increasingly as biomarkers for cancers, autoimmune diseases and inflammatory diseases. They are reported as being freely circulated or encapsulated in microvesicles such as exosomes. This study was performed to elucidate the presence of miRNAs with exosomes in human gingival crevicular fluid (GCF), and the expression profile of miRNA-29 during orthodo...

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Secretory microRNA-29 in Gingival Crevicular Fluid during Canine Retraction

Introduction: Gingival crevicular fluid (GCF) has been widely investigated as a potential source of biomarkers for an individual’s oral and general health information. Various molecules presented in GCF were reported as potential biomarkers for orthodontic tooth movement (OTM). MicroRNAs (miRNAs) are small non-coding RNAs that are involved in post-transcriptional gene regulation. Recently, secr...

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Juveniles versus adults: differences in PGE2 levels in the gingival crevicular fluid during orthodontic tooth movement.

This study aimed to investigate age-related changes in the biosynthetic capacity of prostaglandin E2 (PGE2) in the gingival crevicular fluid (GCF) during one month of orthodontic treatment. Twenty-five juvenile subjects (mean age 13 +/- 2.1 years) and 23 adults (mean age 24 +/- 2.1 years) were included. GCF was collected immediately before the force application at the baseline, 2, 21 and 28 day...

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Bone marker levels in gingival crevicular fluid during orthodontic intrusive tooth movement: a preliminary study.

The aim of the present study is to observe the changes in bone turnover markers, deoxypyridinoline (Dpd), osteocalcin, n-telopeptide (NTx), and bone alkaline phosphatase (balp) during the experimental orthodontic intrusion of maxillary premolar teeth. The study population required fixed appliance therapy involving the extraction of the maxillary first premolar teeth. Gingival crevicular fluid (...

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement.

Orthodontic tooth movement requires extensive re-modelling of the periodontium. Matrix metalloproteinases (MMPs) degrade the extracellular matrix during re-modelling, while their activity is regulated by the tissue inhibitors of metalloproteinases (TIMPs). The aim of this study was to investigate differences in MMP and TIMP levels in the gingival crevicular fluid (GCF) at the resorption and app...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2018

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0194238